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This study reports on the chemical composition and antileishmanial and anticandidal activities of essential oils (EOs) distilled from Schinus molle dried leaves (SM-EO), Cinnamomum cassia branch bark (CC-EO) and their blends against promastigote forms of Leishmania (Leishmania) ama-zonensis and nine Candida strains. Major constituents of SM-EO were spathulenol (26.93%), β-caryophyllene (19.90%), and caryophyllene oxide (12.69%), whereas cinnamaldehyde (60.11%), cinnamyl acetate (20.90%) and (E)-cis-2-methoxycinnamic acid (10.37%) were predominant in CC-EO. SM-EO (IC50 = 21.45 µg/mL) and CC-EO (IC50 = 23.27 µg/mL) displayed good activity against L. amazonensis. SM-EO and CC-EO also proved to be good or moderate activity against nine Can-dida strains, with Minimum Inhibitory Concentration (MIC) values ranging from 31.25 to 250 µg/mL. While the three SM-EO and CC-EO blends were not more active than the EOs tested in-dividually, they exhibited remarkably high antileishmanial activity, with IC50 values ranging between 3.12 and 7.04 µg/mL, which is very similar to the IC50 of amphotericin B (positive con-trol). These results show that SM-EO, CC-EO, and their blends may be considered to participate in the formulation of drugs with antileishmanial and antifungal activities.