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Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization by Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4^+/CD8⁺ T cells expressing IL-22 in AD skin. Our study showed inhibition of the staphylococcal enterotoxins A and B (SEA and SEB) response by Th22 (CD4⁺IL-22⁺IL-17A⁻IFN-γ⁻) cells in AD patients. In contrast, Tc22 (CD8⁺IL-22⁺IL-17A⁻IFN-γ⁻) cells were less susceptible to the inhibitory effects of staphylococcal enterotoxins and exhibited an enhanced response to the …