作者
Bartolome R Celli, Nicholas Locantore, Julie Yates, Ruth Tal-Singer, Bruce E Miller, Per Bakke, Peter Calverley, Harvey Coxson, Courtney Crim, Lisa D Edwards, David A Lomas, Annelyse Duvoix, William MacNee, Stephen Rennard, Edwin Silverman, Jørgen Vestbo, Emiel Wouters, Alvar Agustí, ECLIPSE Investigators
发表日期
2012/5/15
期刊
American journal of respiratory and critical care medicine
卷号
185
期号
10
页码范围
1065-1072
出版商
American Thoracic Society
简介
Rationale: Accurate prediction of mortality helps select patients for interventions aimed at improving outcome.
Objectives: Because chronic obstructive pulmonary disease is characterized by low-grade systemic inflammation, we hypothesized that addition of inflammatory biomarkers to established predictive factors will improve accuracy.
Methods: A total of 1,843 patients enrolled in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study were followed for 3 years. Kaplan-Meier curves, log-rank analysis, and Cox proportional hazards analyses determined the predictive value for mortality of clinical variables, while C statistics assessed the added discriminative power offered by addition of biomarkers.
Measurements and Main Results: At recruitment we measured anthropometrics, spirometry, 6-minute walk distance, dyspnea, BODE index, history of hospitalization, comorbidities, and …
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BR Celli, N Locantore, J Yates, R Tal-Singer, BE Miller… - American journal of respiratory and critical care …, 2012