作者
Michael I Polkey, Martijn A Spruit, Lisa D Edwards, Michael L Watkins, Victor Pinto-Plata, Jørgen Vestbo, Peter MA Calverley, Ruth Tal-Singer, Alvar Agustí, Per S Bakke, Harvey O Coxson, David A Lomas, William MacNee, Stephen Rennard, Edwin K Silverman, Bruce E Miller, Courtney Crim, Julie Yates, Emiel FM Wouters, Bartolome Celli, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study Investigators
发表日期
2013/2/15
期刊
American journal of respiratory and critical care medicine
卷号
187
期号
4
页码范围
382-386
出版商
American Thoracic Society
简介
Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates of the minimal clinically important difference for the 6-minute-walk distance (6MWD) have been derived from narrow cohorts using nonblinded intervention.
Objectives: To determine minimum clinically important difference for change in 6MWD over 1 year as a function of mortality and first hospitalization in an observational cohort of patients with COPD.
Methods: Data from the ECLIPSE cohort were used (n = 2,112). Death or first hospitalization were index events; we measured change in 6MWD in the 12-month period before the event and related change in 6MWD to lung function and St. George’s Respiratory Questionnaire (health status).
Measurement and Main Results: Of subjects with change in the 6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m …
学术搜索中的文章
MI Polkey, MA Spruit, LD Edwards, ML Watkins… - American journal of respiratory and critical care …, 2013