作者
Bipen D Patel, Harvey O Coxson, Sreekumar G Pillai, Alvar GN Agustí, Peter MA Calverley, Claudio F Donner, Barry J Make, Nestor L Muller, Stephen I Rennard, Jørgen Vestbo, Emiel FM Wouters, Melanie P Hiorns, Yasutaka Nakano, Patricia G Camp, Paola V Nasute Fauerbach, Nicholas J Screaton, Edward J Campbell, Wayne H Anderson, Peter D Paré, Robert D Levy, Stephen L Lake, Edwin K Silverman, David A Lomas
发表日期
2008/9/1
期刊
American journal of respiratory and critical care medicine
卷号
178
期号
5
页码范围
500-505
出版商
American Thoracic Society
简介
Rationale: It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families.
Objectives: To determine whether airway wall thickening and emphysema (1) make independent contributions to the severity of COPD and (2) show independent aggregation in families of individuals with COPD.
Methods: Index cases with COPD and their smoking siblings underwent spirometry and were offered high-resolution computed tomography scans of the thorax to assess the severity of airway wall thickening and emphysema.
Measurements and Main Results: A total of 3,096 individuals were recruited to the study, of whom 1,159 (519 probands and 640 siblings) had technically adequate high-resolution computed tomography scans without significant non–COPD-related thoracic …
引用总数
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BD Patel, HO Coxson, SG Pillai, AGN Agustí… - American journal of respiratory and critical care …, 2008