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Background

Lung cancer is one of the primary causes of death worldwide. According to Global Burden of Disease (GBD), highest prevalence and mortality of NSCLC is found in men in India. These typically may present as nodules or masses in the lung. The circulating microRNAs delineate stable and reproducible markers for lung cancer and may play important role in non-invasive diagnostic marker. We have previously discovered miRNA signatures in the exhaled breath condensate (EBC) that are suitable for early diagnostics of various lung diseases. Since miRNAs have roles in the pathogenesis of lung diseases, they can be potentially useful in the early diagnosis of lung cancer and may as well complement the other conventional investigative methods such as low dose computerized tomography (LDCT) to avoid high false positive rates. Due to paucity of thoracic surgeons and interventional bronchoscopists in …