作者
Sooncheol Lee, Shobha Vasudevan
发表日期
2012/11/2
来源
Ten Years of Progress in GW/P Body Research
页码范围
97-126
出版商
Springer New York
简介
MicroRNAs are small noncoding RNA regulatory molecules that control gene expression by guiding associated effector complexes to other RNAs via sequence-specific recognition of target sites. Misregulation of microRNAs leads to a wide range of diseases including cancers, inflammatory and developmental disorders. MicroRNAs were found to mediate deadenylation-dependent decay and translational repression of messages through partially complementary microRNA target sites in the 3′-UTR (untranslated region). A growing series of studies has demonstrated that microRNAs and their associated complexes (microRNPs) elicit alternate functions that enable stimulation of gene expression in addition to their assigned repressive roles. These reports, discussed in this chapter, indicate that microRNA-mediated effects via natural 3′ and 5′-UTRs can be selective and controlled, dictated by the RNA …
学术搜索中的文章
S Lee, S Vasudevan - Ten Years of Progress in GW/P Body Research, 2012