作者
Susan S Huang, Kristen M Johnson, G Thomas Ray, Peter Wroe, Tracy A Lieu, Matthew R Moore, Elizabeth R Zell, Jeffrey A Linder, Carlos G Grijalva, Joshua P Metlay, Jonathan A Finkelstein
发表日期
2011/4/18
期刊
Vaccine
卷号
29
期号
18
页码范围
3398-3412
出版商
Elsevier
简介
BACKGROUND
Streptococcus pneumoniae continues to cause a variety of common clinical syndromes, despite vaccination programs for both adults and children. The total US burden of pneumococcal disease is unknown.
METHODS
We constructed a decision tree-based model to estimate US healthcare utilization and costs of pneumococcal disease in 2004. Data were obtained from the 2004–2005 National (Hospital) Ambulatory Medical Care Surveys (outpatient visits, antibiotics) and the National Hospital Discharge Survey (hospitalization rates), and CDC surveillance data. Other assumptions regarding the incidence of each syndrome due to pneumococcus, expected health outcomes, and healthcare utilization were derived from literature and expert opinion. Healthcare and time costs used 2007 dollars.
RESULTS
We estimate that, in 2004, pneumococcal disease caused 4.0 million illness episodes, 22,000 …
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