作者
Max Lam, Chia-Yen Chen, Zhiqiang Li, Alicia R Martin, Julien Bryois, Xixian Ma, Helena Gaspar, Masashi Ikeda, Beben Benyamin, Brielin C Brown, Ruize Liu, Wei Zhou, Lili Guan, Yoichiro Kamatani, Sung-Wan Kim, Michiaki Kubo, Agung AAA Kusumawardhani, Chih-Min Liu, Hong Ma, Sathish Periyasamy, Atsushi Takahashi, Zhida Xu, Hao Yu, Feng Zhu, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Indonesia Schizophrenia Consortium, Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN), Wei J Chen, Stephen Faraone, Stephen J Glatt, Lin He, Steven E Hyman, Hai-Gwo Hwu, Steven A McCarroll, Benjamin M Neale, Pamela Sklar, Dieter B Wildenauer, Xin Yu, Dai Zhang, Bryan J Mowry, Jimmy Lee, Peter Holmans, Shuhua Xu, Patrick F Sullivan, Stephan Ripke, Michael C O’Donovan, Mark J Daly, Shengying Qin, Pak Sham, Nakao Iwata, Kyung S Hong, Sibylle G Schwab, Weihua Yue, Ming Tsuang, Jianjun Liu, Xiancang Ma, René S Kahn, Yongyong Shi, Hailiang Huang
发表日期
2019/12
期刊
Nature genetics
卷号
51
期号
12
页码范围
1670-1678
出版商
Nature Publishing Group US
简介
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of …
学术搜索中的文章
M Lam, CY Chen, Z Li, AR Martin, J Bryois, X Ma… - Nature genetics, 2019