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Multiple neurological diseases are becoming increasingly common, posing a major public health concern around the world. The multifactorial pathophysiology of this debilitating disease, as well as the diverse effects of active constituents of microalgal medicine, as well as the drawbacks and lack of clinical treatments, may advocate for the discovery of new natural compounds with strong neuroprotective potential for treatment. Spirulina is a free-floating filamentous microalga that belongs to the cyanobacteria class and contains a variety of bioactive colored components such as C-phycocyanin (C-Pc), carotenoids, and chlorophyll. Modern pharmacological and molecular docking studies have demonstrated that Spirulina has disease-modifying therapeutic effects against these disorders, including neuroprotection, protein aggregate clearance, and neuroinflammation regulation. The study’s goal is to determine the …