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Free radicals are involved in neurodegenerative disorders such as ischemia and aging. Treatments with Spirulina have been shown to reduce neurodegenerative changes in animals. The present study has been designed to examine the potential neuroprotective effects of Spirulina platensis (Sp.) against AlCl₃-induced neurotoxicity in different regions of brain (cerebral cortex, hippocampus and hind brain) of rats. AlCl₃ caused significant increase in thiobarbituric acid-reactive substances, tumor necrosis factor-α and aluminium concentration, while decrease glutathione, total antioxidant capacity, antioxidant enzymes (SOD, CAT, GST and GPx), total thiol content, monoamine oxidase, Na⁺-K⁺ ATPase and total ATPase. These results were confirmed by histopathological and fluorescence examination of different regions of brain. Cerebral cortex and hippocampus of AlCl3 showed loss of normal structure, neuronal …