作者
Michelle Sholzberg, Grace H Tang, Elnara Negri, Hassan Rahhal, Lisa Baumann Kreuziger, Carlos E Pompilio, Paula James, Michael Fralick, Musaad AlHamzah, Faris Alomran, Eric Tseng, Gloria Lim, David Lillicrap, Marc Carrier, Fionnuala Ní Áinle, Andrew Beckett, Bruno R da Costa, Kevin Thorpe, Saskia Middeldorp, Agnes Lee, Mary Cushman, Peter Jüni
发表日期
2021/12
期刊
Trials
卷号
22
页码范围
1-4
出版商
BioMed Central
简介
Objectives
To determine the effect of therapeutic anticoagulation, with low molecular weight heparin (LMWH) or unfractionated heparin (UFH, high dose nomogram), compared to standard care in hospitalized patients admitted for COVID-19 with an elevated D-dimer on the composite outcome of intensive care unit (ICU) admission, non-invasive positive pressure ventilation, invasive mechanical ventilation or death up to 28 days.
Trial design
Open-label, parallel, 1:1, phase 3, 2-arm randomized controlled trial
Participants
The study population includes hospitalized adults admitted for COVID-19 prior to the development of critical illness. Excluded individuals are those where the bleeding risk or risk of transfusion would generally be considered unacceptable, those already therapeutically anticoagulated and those who have …
学术搜索中的文章
M Sholzberg, GH Tang, E Negri, H Rahhal… - Trials, 2021