作者
Rebecca E Graff, Taylor B Cavazos, Khanh K Thai, Linda Kachuri, Sara R Rashkin, Joshua D Hoffman, Stacey E Alexeeff, Maruta Blatchins, Travis J Meyers, Lancelote Leong, Caroline G Tai, Nima C Emami, Douglas A Corley, Lawrence H Kushi, Elad Ziv, Stephen K Van Den Eeden, Eric Jorgenson, Thomas J Hoffmann, Laurel A Habel, John S Witte, Lori C Sakoda
发表日期
2021/2/12
期刊
Nature Communications
卷号
12
期号
1
页码范围
1-9
出版商
Nature Publishing Group
简介
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and UK Biobank (48,969 cases, 359,802 controls). Within cohorts, each PRS is evaluated in multivariable logistic regression models against all other cancer types. Results are then meta-analyzed across cohorts. Ten positive and one inverse cross-cancer associations are found after multiple testing correction. Two pairs show bidirectional associations; the melanoma PRS is positively associated with oral cavity/pharyngeal cancer and vice versa, whereas the lung cancer PRS is positively associated with oral cavity/pharyngeal cancer, and the oral cavity/pharyngeal cancer PRS is inversely associated with lung cancer. Overall, we validate …
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RE Graff, TB Cavazos, KK Thai, L Kachuri, SR Rashkin… - Nature communications, 2021