作者
Raffaele Vecchione, Sara Coppola, Eliana Esposito, Costantino Casale, Veronica Vespini, Simonetta Grilli, Pietro Ferraro, Paolo Antonio Netti
发表日期
2014/6
期刊
Advanced Functional Materials
卷号
24
期号
23
页码范围
3515-3523
简介
Hypodermic needle injection is still the most common method of drug delivery despite its numerous limitations and drawbacks, such as pain, one‐shot administration, and risk of infection. Seeking a viable, safe, and pain‐free alternative to the over 16 billion injections per year has therefore become a top priority for our modern technological society. Here, a system that uses a pyroelectric cartridge in lieu of the syringe piston as a potential solution is discussed. Upon stimulation, the cartridge electro‐draws, at room temperature, an array of drug‐encapsulated, biodegradable polymer microneedles, able to deliver into hypodermic tissue both hydrophobic and hydrophilic bioactive agents, according to a predefined chrono‐programme. This mould‐free and contact‐free method permits the fabrication of biodegradable polymer microneedles into a ready‐to‐use configuration. In fact, they are formed on a flexible substrate …
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R Vecchione, S Coppola, E Esposito, C Casale… - Advanced Functional Materials, 2014