作者
Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Shin Watanabe, Masataka Nishiga, Shunsuke Usami, Masayasu Izuhara, Tetsushi Nakao, Tomohiro Nishino, Kinya Otsu, Toru Kita, Takeshi Kimura, Koh Ono
发表日期
2015/1/16
期刊
Circulation research
卷号
116
期号
2
页码范围
279-288
出版商
Lippincott Williams & Wilkins
简介
Rationale:
In some patients with type 2 diabetes mellitus (DM) without hypertension, cardiac hypertrophy and attenuated cardiac function are observed, and this insult is termed diabetic cardiomyopathy. To date, microRNA (miRNAs or miR) functions in diabetic cardiomyopathy remain to be elucidated.
Objective:
To clarify the functions of miRNAs involved in diabetic cardiomyopathy caused by type 2 DM.
Methods and Results:
C57BL/6 mice were fed a high-fat diet (HFD) for 20 weeks, which induced obesity and type 2 DM. miRNA microarray analyses and real-time polymerase chain reaction revealed that miR-451 levels were significantly increased in the type 2 DM mouse hearts. Because excess supply of saturated fatty acids is a cause of diabetic cardiomyopathy, we stimulated neonatal rat cardiac myocytes with palmitic acid and confirmed that miR-451 expression was increased in a dose- and time-dependent …
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Y Kuwabara, T Horie, O Baba, S Watanabe, M Nishiga… - Circulation research, 2015