作者
Giovanni Ferrara, Monica Losi, Roberto D'Amico, Pietro Roversi, Roberto Piro, Marisa Meacci, Barbara Meccugni, Ilaria Marchetti Dori, Alessandro Andreani, Barbara Maria Bergamini, Cristina Mussini, Fabio Rumpianesi, Leonardo M Fabbri, Luca Richeldi
发表日期
2006/4/22
期刊
The Lancet
卷号
367
期号
9519
页码范围
1328-1334
出版商
Elsevier
简介
Background
Two commercial blood assays for the diagnosis of latent tuberculosis infection—T-SPOT.TB and QuantiFERON-TB Gold—have been separately compared with the tuberculin skin test. Our aim was to compare the efficacy of all three tests in the same population sample.
Methods
We did a prospective study in 393 consecutively enrolled patients who were tested simultaneously with T-SPOT.TB and QuantiFERON-TB Gold because of suspected latent or active tuberculosis. 318 patients also had results available for a tuberculin skin test.
Findings
Overall agreement with the skin test was similar (T-SPOT.TB κ=0·508, QuantiFERON-TB Gold κ=0·460), but fewer BCG-vaccinated individuals were identified as positive by the two blood assays than by the tuberculin skin test (p=0·003 for T-SPOT.TB and p<0.0001 for QuantiFERON-TB Gold). Indeterminate results were significantly more frequent with QuantiFERON …
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G Ferrara, M Losi, R D'Amico, P Roversi, R Piro… - The Lancet, 2006