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Protein drug delivery has become an important area of research due to the large number of recombinant proteins that are now being investigated for therapeutic applications. However, proteins have very short in vivo half-lives and they require multiple injections to achieve the desired therapeutic effect. One of the way to increase the therapeutic efficiency of these polypeptides is encapsulating them in a sustained dosage form that is capable of releasing the macromolecule cori-tinuously and at a controlled rate (1). Typically, proteins have been loaded into the polymers like poly (lactic acid)(PLA), poly (lactic acid-co-glycolic acid)(PLGA) and PLGA—PEG—PLGA (2, 3). Fabrication of drug delivery systems using such polymers involves the use of organic solvents or heat that results in protein denaturation and loss of bioactivity. Many problems in loading proteins can be overcome by the use of polymeric hydrogels …