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Important functional connections within the default mode network (DMN) are disrupted in Alzheimer's disease (AD), likely from amyloid-beta (Aβ) plaque-associated neuronal toxicity. Here, we sought to determine if pathological effects of Aβ amyloid plaques could be seen, even in the absence of a task, by examining functional connectivity in cognitively normal participants with and without preclinical amyloid deposition.

Participants with Alzheimer's disease (AD) (n = 35) were compared with 68 cognitively normal participants who were further subdivided by positron emission tomography (PET) Pittsburgh Compound-B (PIB) imaging into those without evidence of brain amyloid (PIB−) and those with brain amyloid (PIB+) deposition.

Resting state functional magnetic resonance imaging (fMRI) demonstrated that, compared with the PIB− group, the PIB+ group differed significantly …