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Calcium phosphates such as hydroxyapatite (HA) and tricalcium phosphate (TCP) have been performing important roles in the construction of 3D scaffolds for bone tissue engineering due to their biocompatibility, osteocondutivity [1] and various degradation rates. In addition, hydrolytically degradable polyesters such as poly (glycolic acid)(PGA), poly (lactic acid)(PLA) and their copolymers (PLGA), have also been widely used for scaffolds manufacture due to their good biodegradability and biocompatibility, as well as innocuous degradation products [2, 3]. The aim of this study is to combine the advantages of those two biomaterials in order to produce scaffolds for guided bone regeneration by the solvent casting technique. The scaffolds were produced by dilution of the polymer (PLGA) in chlorophorm and following addition of the biphasic ceramic hydroxyapatite/B-TCP 70/30 and the porogenic agent, saccharose. The mixture was casted in a medical grade silicon mold and left there until complete evaporation of the solvent. After, the prototypes were washed in polyvinyl alcohol in order to remove all the saccharose. Cytotoxicity and biocompatibility studies in the osteoblasts culture results showed that there was cellular adhesion, collagen production and cellular proliferation, meaning that the scaffolds are suitable for tissue engineering.