作者
Nikolaos Pyrgidis, Faysal A Yafi, Ioannis Sokolakis, Fotios Dimitriadis, Ioannis Mykoniatis, Giorgio Ivan Russo, Paolo Verze, Georgios Hatzichristodoulou
发表日期
2022/9/1
来源
European Urology Focus
卷号
8
期号
5
页码范围
1520-1530
出版商
Elsevier
简介
Context
In patients with Peyronie’s disease (PD), oral, injected, or topical agents provide limited efficacy. In this setting, combination of two or more conservative treatments may improve symptoms further.
Objective
To explore the effects of available conservative combination therapies for active and stable PD through a systematic review and meta-analysis.
Evidence acquisition
We searched multiple databases and sources of gray literature until June 2021. We included randomized or observational comparative studies assessing any conservative combination therapies for PD. We undertook a random-effect meta-analysis when at least two studies employed the same treatment modality (PROSPERO: CRD42021224517).
Evidence synthesis
Overall, 13 studies on active PD and ten on stable PD (1962 participants) were included. Most included studies raised methodological concerns. In patients with active or stable PD …
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N Pyrgidis, FA Yafi, I Sokolakis, F Dimitriadis… - European Urology Focus, 2022