作者
Ioannis Mykoniatis, Nikolaos Pyrgidis, Ioannis Sokolakis, Andreas Ouranidis, Petros Sountoulides, Anna-Bettina Haidich, Koenraad van Renterghem, Georgios Hatzichristodoulou, Dimitrios Hatzichristou
发表日期
2021/2/1
来源
JAMA network open
卷号
4
期号
2
页码范围
e2036337-e2036337
出版商
American Medical Association
简介
Importance
Combining 2 first-line treatments for erectile dysfunction (ED) or initiating other modalities in addition to a first-line therapy may produce beneficial outcomes.
Objective
To assess whether different ED combination therapies were associated with improved outcomes compared with first-line ED monotherapy in various subgroups of patients with ED.
Data Sources
Studies were identified through a systematic search in MEDLINE, Cochrane Library, and Scopus from inception of these databases to October 10, 2020.
Study Selection
Randomized clinical trials or prospective interventional studies of the outcomes of combination therapy vs recommended monotherapy in men with ED were identified. Only comparative human studies, which evaluated the change from baseline of self-reported erectile function using validated questionnaires, that were published in any language were included.
Data Extraction and …
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I Mykoniatis, N Pyrgidis, I Sokolakis, A Ouranidis… - JAMA network open, 2021