作者
Evangelos Poulios, Ioannis Mykoniatis, Nikolaos Pyrgidis, Filimon Zilotis, Paraskevi Kapoteli, Dimitrios Kotsiris, Dimitrios Kalyvianakis, Dimitrios Hatzichristou
发表日期
2021/5
期刊
The journal of sexual medicine
卷号
18
期号
5
页码范围
926-935
出版商
Oxford University Press
简介
Background
Animal studies postulate that platelet-rich plasma (PRP) injections improve key elements of the pathophysiologic mechanisms leading to erectile dysfunction (ED).
Aim
To conduct the first double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of PRP injections in patients with mild and moderate ED.
Methods
Sixty sexually active patients with mild and moderate ED were randomly assigned to two sessions, with a one-month difference, of 10 mL PRP (n = 30) or placebo (n = 30) intracavernosal injections. An FDA-approved separation system was used. Patients were evaluated at 1, 3 and 6 months after completion of the treatment protocol. A per-protocol analysis was applied. All participants withheld any ED treatment during the trial.
Outcomes
The achievement of minimal clinically important …
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E Poulios, I Mykoniatis, N Pyrgidis, F Zilotis, P Kapoteli… - The journal of sexual medicine, 2021