作者
Scott J Moeller, Thomas Maloney, Muhammad A Parvaz, Jonathan P Dunning, Nelly Alia-Klein, Patricia A Woicik, Greg Hajcak, Frank Telang, Gene-Jack Wang, Nora D Volkow, Rita Z Goldstein
发表日期
2009/7/15
期刊
Biological psychiatry
卷号
66
期号
2
页码范围
169-176
出版商
Elsevier
简介
BACKGROUND
Individuals with cocaine use disorder (CUD) chose cocaine over nondrug rewards. In two newly designed laboratory tasks with pictures, we document this modified choice outside of a cocaine administration paradigm.
METHODS
Choice for viewing cocaine, pleasant, unpleasant, or neutral pictures—under explicit contingencies (choice made between two fully visible side-by-side images) and under more implicit contingencies (selections made between pictures hidden under flipped-over cards)—was examined in 20 CUD and 20 matched healthy control subjects. Subjects also provided self-reported ratings of each picture's pleasantness and arousal.
RESULTS
Under both contingencies, CUD subjects chose to view more cocaine pictures than control subjects, group differences that were not fully explained by the self-reported picture ratings. Furthermore, whereas CUD subjects' choice for viewing …
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