作者
Holly E Richter, Michael E Albo, Halina M Zyczynski, Kimberly Kenton, Peggy A Norton, Larry T Sirls, Stephen R Kraus, Toby C Chai, Gary E Lemack, Kimberly J Dandreo, R Edward Varner, Shawn Menefee, Chiara Ghetti, Linda Brubaker, Ingrid Nygaard, Salil Khandwala, Thomas A Rozanski, Harry Johnson, Joseph Schaffer, Anne M Stoddard, Robert L Holley, Charles W Nager, Pamela Moalli, Elizabeth Mueller, Amy M Arisco, Marlene Corton, Sharon Tennstedt, T Debuene Chang, E Ann Gormley, Heather J Litman
发表日期
2010/6/3
期刊
New England Journal of Medicine
卷号
362
期号
22
页码范围
2066-2076
出版商
Massachusetts Medical Society
简介
Background
Midurethral slings are increasingly used for the treatment of stress incontinence, but there are limited data comparing types of slings and associated complications.
Methods
We performed a multicenter, randomized equivalence trial comparing outcomes with retropubic and transobturator midurethral slings in women with stress incontinence. The primary outcome was treatment success at 12 months according to both objective criteria (a negative stress test, a negative pad test, and no retreatment) and subjective criteria (self-reported absence of symptoms, no leakage episodes recorded, and no retreatment). The predetermined equivalence margin was ±12 percentage points.
Results
A total of 597 women were randomly assigned to a study group; 565 (94.6%) completed the 12-month assessment. The rates of objectively assessed treatment success were 80.8% in the retropubic-sling group and 77.7 …
引用总数
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HE Richter, ME Albo, HM Zyczynski, K Kenton… - New England Journal of Medicine, 2010