作者
Holly E Richter, Kathryn L Burgio, Linda Brubaker, Ingrid E Nygaard, Wen Ye, Alison Weidner, Catherine S Bradley, Victoria L Handa, Diane Borello-France, Patricia S Goode, Halina Zyczynski, Emily S Lukacz, Joseph Schaffer, Matthew Barber, Susan Meikle, Cathie Spino, Pelvic Floor Disorders Network
发表日期
2010/3/1
期刊
Obstetrics & Gynecology
卷号
115
期号
3
页码范围
609-617
出版商
LWW
简介
OBJECTIVE: To compare the effectiveness of a continence pessary to evidence-based behavioral therapy for stress incontinence and to assess whether combined pessary and behavioral therapy is superior to single-modality therapy.
METHODS: This was a multisite, randomized clinical trial (Ambulatory Treatments for Leakage Associated with Stress Incontinence [ATLAS]) that randomly assigned 446 women with stress incontinence to pessary, behavioral therapy, or combined treatment. Primary outcome measures, at 3 months, were Patient Global Impression of Improvement and the stress incontinence subscale of the Pelvic Floor Distress Inventory. A priori, to be considered clinically superior, combination therapy had to be better than both single-modality therapies. Outcome measures were repeated at 6 and 12 months. Primary analyses used an intention-to-treat approach.
RESULTS: At 3 months, scores from 40 …
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HE Richter, KL Burgio, L Brubaker, IE Nygaard, W Ye… - Obstetrics & Gynecology, 2010