作者
Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, Jocelyn R Farmer, Hugues Allard-Chamard, Vinay S Mahajan, Alicja Piechocka-Trocha, Kristina Lefteri, Matthew Osborn, Julia Bals, Yannic C Bartsch, Nathalie Bonheur, Timothy M Caradonna, Josh Chevalier, Fatema Chowdhury, Thomas J Diefenbach, Kevin Einkauf, Jon Fallon, Jared Feldman, Kelsey K Finn, Pilar Garcia-Broncano, Ciputra Adijaya Hartana, Blake M Hauser, Chenyang Jiang, Paulina Kaplonek, Marshall Karpell, Eric C Koscher, Xiaodong Lian, Hang Liu, Jinqing Liu, Ngoc L Ly, Ashlin R Michell, Yelizaveta Rassadkina, Kyra Seiger, Libera Sessa, Sally Shin, Nishant Singh, Weiwei Sun, Xiaoming Sun, Hannah J Ticheli, Michael T Waring, Alex L Zhu, Galit Alter, Jonathan Z Li, Daniel Lingwood, Aaron G Schmidt, Mathias Lichterfeld, Bruce D Walker, G Yu Xu, Robert F Padera, Shiv Pillai
发表日期
2020/10/1
期刊
Cell
卷号
183
期号
1
页码范围
143-157. e13
出版商
Elsevier
简介
Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability, as seen with other human coronavirus epidemics. To address the underlying etiology, we examined post mortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the absence of germinal centers and a striking reduction in Bcl-6+ germinal center B cells but preservation of AID+ B cells. Absence of germinal centers correlated with an early specific block in Bcl-6+ TFH cell differentiation together with an increase in T-bet+ TH1 cells and aberrant extra-follicular TNF-α accumulation. Parallel peripheral blood studies revealed loss of transitional and follicular B cells in severe disease and accumulation of SARS-CoV-2-specific "disease-related" B cell populations. These data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease …
学术搜索中的文章
N Kaneko, HH Kuo, J Boucau, JR Farmer… - Cell, 2020