作者
Junhao Yan, Yingying Qin, Han Zhao, Yun Sun, Fei Gong, Rong Li, Xiaoxi Sun, Xiufeng Ling, Hong Li, Cuifang Hao, Jichun Tan, Jing Yang, Yimin Zhu, Fenghua Liu, Dawei Chen, Daimin Wei, Juanjuan Lu, Tianxiang Ni, Wei Zhou, Keliang Wu, Yuan Gao, Yuhua Shi, Yao Lu, Ting Zhang, Wei Wu, Xiang Ma, Hailan Ma, Jing Fu, Junqiang Zhang, Qingxia Meng, Heping Zhang, Richard S Legro, Zi-Jiang Chen
发表日期
2021/11/25
期刊
New England Journal of Medicine
卷号
385
期号
22
页码范围
2047-2058
出版商
Massachusetts Medical Society
简介
Background
Embryo selection with preimplantation genetic testing for aneuploidy (PGT-A) may improve pregnancy outcomes after initial embryo transfer. However, it remains uncertain whether PGT-A improves the cumulative live-birth rate as compared with conventional in vitro fertilization (IVF).
Methods
In this multicenter, randomized, controlled trial, we randomly assigned subfertile women with three or more good-quality blastocysts to undergo either PGT-A or conventional IVF; all the women were between 20 and 37 years of age. Three blastocysts were screened by next-generation sequencing in the PGT-A group or were chosen by morphologic criteria in the conventional-IVF group and then were successively transferred one by one. The primary outcome was the cumulative live-birth rate after up to three embryo-transfer procedures within 1 year after randomization. We hypothesized that the use of PGT-A …
学术搜索中的文章
J Yan, Y Qin, H Zhao, Y Sun, F Gong, R Li, X Sun… - New England Journal of Medicine, 2021