作者
Theo GM Van Erp, Derrek P Hibar, Jerod M Rasmussen, David C Glahn, Godfrey D Pearlson, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Unn K Haukvik, Anders M Dale, Ingrid Melle, Cecilie B Hartberg, Oliver Gruber, Bernd Kraemer, David Zilles, Gary Donohoe, Sinead Kelly, Colm McDonald, Derek W Morris, Dara M Cannon, Aiden Corvin, Marise WJ Machielsen, Laura Koenders, Laurens de Haan, Dick J Veltman, Theodore D Satterthwaite, Daniel H Wolf, Ruben C Gur, Raquel E Gur, Steven G Potkin, Daniel H Mathalon, Bryon A Mueller, Adrian Preda, Fabio Macciardi, Stefan Ehrlich, Esther Walton, Johanna Hass, Vince D Calhoun, Henry J Bockholt, Scott R Sponheim, Jody M Shoemaker, Neeltje EM van Haren, HE Hulshoff Pol, Roel A Ophoff, René S Kahn, Roberto Roiz-Santiañez, Benedicto Crespo-Facorro, Lei Wang, Kathryn I Alpert, Erik G Jönsson, Rali Dimitrova, Catherine Bois, Heather C Whalley, Andrew M McIntosh, Stephen M Lawrie, Ryota Hashimoto, Paul M Thompson, Jessica A Turner
发表日期
2016/4
期刊
Molecular psychiatry
卷号
21
期号
4
页码范围
547-553
出版商
Nature Publishing Group
简介
The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls, assessed with standardized methods at 15 centers worldwide. We identified subcortical brain volumes that differentiated patients from controls, and ranked them according to their effect sizes. Compared with healthy controls, patients with schizophrenia had smaller hippocampus (Cohen’s d=− 0.46), amygdala (d=− 0.31), thalamus (d=− 0.31), accumbens (d=− 0.25) and intracranial volumes (d=− 0.12), as well as larger pallidum (d= 0.21) and lateral ventricle volumes (d= 0.37). Putamen and pallidum volume augmentations were positively associated with duration of illness and hippocampal deficits …
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TGM Van Erp, DP Hibar, JM Rasmussen, DC Glahn… - Molecular psychiatry, 2016