作者
Marija Milovanovic, Vladislav Volarevic, Gordana Radosavljevic, Ivan Jovanovic, Nada Pejnovic, Nebojsa Arsenijevic, Miodrag L Lukic
发表日期
2012/4
来源
Immunologic research
卷号
52
页码范围
89-99
出版商
Springer-Verlag
简介
Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, binds to its plasma membrane receptor, heterodimeric complex consisted of membrane-bound ST2L and IL-1R accessory protein, inducing NFkB and MAPK activation. IL-33 exists as a nuclear precursor and may act as an alarmin, when it is released after cell damage or as negative regulator of NFκB gene transcription, when acts in an intracrine manner. ST2L is expressed on several immune cells: Th2 lymphocytes, NK, NKT and mast cells and on cells of myeloid lineage: monocytes, dendritic cells and granulocytes. IL-33/ST2 axis can promote both Th1 and Th2 immune responses depending on the type of activated cell and microenvironment and cytokine network in damaged tissue. We previously described and discuss here the important role of IL-33/ST2 axis in experimental models of type 1 diabetes, experimental autoimmune …
引用总数
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M Milovanovic, V Volarevic, G Radosavljevic… - Immunologic research, 2012