作者
Samir Attoub, Milena Mechkarska, Agnes Sonnevend, Gordana Radosavljevic, Ivan Jovanovic, Miodrag L Lukic, J Michael Conlon
发表日期
2013/1/1
期刊
Peptides
卷号
39
页码范围
95-102
出版商
Elsevier
简介
The host-defense peptide, esculentin-2CHa (GFSSIFRGVA10KFASKGLGK D20LAKLGVDLVA30 CKISKQC) shows potent (MIC≤6μM) growth inhibitory activity against clinical isolates of multidrug-resistant strains of Staphylococcus aureus, Acinetobacter baumannii, and Stenotrophomonas maltophilia and differential cytotoxic activity against human erythrocytes (LC50=150μM) and human non-small cell lung adenocarcinoma A549 cells (LC50=10μM). Esculentin-2CHa significantly (P<0.01) stimulates the release of the anti-inflammatory cytokine IL-10 by mouse lymphoid cells and elevates its production after stimulation with concanavalin A and significantly (P<0.05) stimulates TNF-α production by peritoneal macrophages. Effects on IL-6 and IL-1β production were not significant. Removal of the hydrophobic N-terminal hexapeptide (GFSSIF) from esculentin-2CHa results in abolition of growth inhibitory activity …
学术搜索中的文章
S Attoub, M Mechkarska, A Sonnevend… - Peptides, 2013