作者
Christina L Roland, Anthony D Yang, Matthew HG Katz, Deyali Chatterjee, Huamin Wang, Heather Lin, Jean N Vauthey, Peter W Pisters, Gauri R Varadhachary, Robert A Wolff, Christopher H Crane, Jeffrey E Lee, Jason B Fleming
发表日期
2015/4
期刊
Annals of surgical oncology
卷号
22
页码范围
1168-1175
出版商
Springer US
简介
Background
The use of neoadjuvant therapy (NAC) for the treatment of potentially resectable pancreatic cancer remains controversial. In this study, we sought to evaluate cancer-specific endpoints in patients undergoing a NAC versus a surgery-first (SF) approach with specific emphasis on lymph node metastases.
Methods
A total of 222 patients who underwent NAC and 85 patients who underwent SF were identified from 1990 to 2008 and compared for cancer-related endpoints. Peripancreatic lymph nodes from 135 neoadjuvant therapy patients were evaluated for histologic tumor regression.
Results
Patients who underwent NAC followed by surgery had improved overall survival and time to local recurrence compared with the SF approach. NAC patients were less likely to have lymph node metastases (p = 0.001 …
学术搜索中的文章
CL Roland, AD Yang, MHG Katz, D Chatterjee, H Wang… - Annals of surgical oncology, 2015