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Objective (s):

Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice.

Materials and Methods:

Met (1 and 10 mg/kg/po), was administrated daily in D-gal-received (500 mg/kg/po) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF).

Results:

Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved …