作者
Fereshteh Dehnamaki, Akbar Karimi, Ali Asghar Pilevarian, Iman Fatemi, Elham Hakimizadeh, Ayat Kaeidi, Mohammad Allahtavakoli, Mohammad Reza Rahmani, Morteza Khademalhosseini, Gholamreza Bazmandegan
发表日期
2019/1/2
期刊
Acta Chirurgica Belgica
卷号
119
期号
1
页码范围
31-37
出版商
Taylor & Francis
简介
Background: Cisplatin (CP) is a synthetic and anticancer drug, and one of the major side effects of CP is nephrotoxicity. This study was done to evaluate the renoprotective effects of troxerutin (Tro) in nephrotoxicity induced by CP in male mice.
Methods: In this experimental study, 28 male mice were divided randomly into four groups. Mice were treated with CP (20 mg/kg, i.p.) then Tro (75 and 150 mg/kg/day, po) was administered for three consecutive days. Blood samples were collected to determine serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The kidney tissues were used for histological examination and biochemical assays. Malondialdehyde (MDA) level, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity were assessed in renal tissue.
Results: Results showed a significant increase in the Cr, BUN and MDA levels and a significant decrease in the renal SOD and GPx activity by …
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F Dehnamaki, A Karimi, AA Pilevarian, I Fatemi… - Acta Chirurgica Belgica, 2019