作者
Peter Pronovost, Dale Needham, Sean Berenholtz, David Sinopoli, Haitao Chu, Sara Cosgrove, Bryan Sexton, Robert Hyzy, Robert Welsh, Gary Roth, Joseph Bander, John Kepros, Christine Goeschel
发表日期
2006/12/28
期刊
New England journal of medicine
卷号
355
期号
26
页码范围
2725-2732
出版商
Massachusetts Medical Society
简介
Background
Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal.
Methods
We conducted a collaborative cohort study predominantly in ICUs in Michigan. An evidence-based intervention was used to reduce the incidence of catheter-related bloodstream infections. Multilevel Poisson regression modeling was used to compare infection rates before, during, and up to 18 months after implementation of the study intervention. Rates of infection per 1000 catheter-days were measured at 3-month intervals, according to the guidelines of the National Nosocomial Infections Surveillance System.
Results
A total of 108 ICUs agreed to participate in the study, and 103 reported data. The analysis included 1981 ICU-months of data and 375,757 catheter-days. The median rate of catheter-related bloodstream infection per 1000 catheter-days decreased from …
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P Pronovost, D Needham, S Berenholtz, D Sinopoli… - New England journal of medicine, 2006