作者
William H Yong, Pramod V Butte, Brian K Pikul, Javier A Jo, Qiyin Fang, Thanassis Papaioannou, Keith L Black, Laura Marcu
发表日期
2006/5
期刊
Frontiers in bioscience: a journal and virtual library
卷号
11
页码范围
1255
出版商
NIH Public Access
简介
Neuropathology frozen section diagnoses are difficult in part because of the small tissue samples and the paucity of adjunctive rapid intraoperative stains. This study aims to explore the use of time-resolved laser-induced fluorescence spectroscopy as a rapid adjunctive tool for the diagnosis of glioma specimens and for distinction of glioma from normal tissues intraoperatively. Ten low grade gliomas, 15 high grade gliomas without necrosis, 6 high grade gliomas with necrosis and/or radiation effect, and 14 histologically uninvolved “normal” brain specimens are spectroscopicaly analyzed and contrasted. Tissue autofluorescence was induced with a pulsed Nitrogen laser (337 nm, 1.2 ns) and the transient intensity decay profiles were recorded in the 370-500 nm spectral range with a fast digitized (0.2 ns time resolution). Spectral intensities and time-dependent parameters derived from the time-resolved spectra of each …
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WH Yong, PV Butte, BK Pikul, JA Jo, Q Fang… - Frontiers in bioscience: a journal and virtual library, 2006