作者
Wen Shi, Guohui Yan, Yamin Li, Haotian Li, Tingting Liu, Cong Sun, Guangbin Wang, Yi Zhang, Yu Zou, Dan Wu
发表日期
2020/12/1
期刊
Neuroimage
卷号
223
页码范围
117316
出版商
Academic Press
简介
MRI-based brain age prediction has been widely used to characterize normal brain development, and deviations from the typical developmental trajectory are indications of brain abnormalities. Age prediction of the fetal brain remains unexplored, although it can be of broad interest to prenatal examination given the limited diagnostic tools available for assessment of the fetal brain. In this work, we built an attention-based deep residual network based on routine clinical T2-weighted MR images of 659 fetal brains, which achieved an overall mean absolute error of 0.767 weeks and R2 of 0.920 in fetal brain age prediction. The predictive uncertainty and estimation confidence were simultaneously quantified from the network as markers for detecting fetal brain anomalies using an ensemble method. The novel markers overcame the limitations in conventional brain age estimation and demonstrated promising diagnostic …
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