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To investigate the effects of frequency drift on chemical exchange saturation transfer (CEST) imaging at 3T, and to propose a new sequence for correcting artifacts attributed to B₀ drift in real time.

A frequency‐stabilized CEST (FS‐CEST) imaging sequence was proposed by adding a frequency stabilization module to the conventional non‐frequency‐stabilized CEST (NFS‐CEST) sequence, which consisted of a small tip angle radiofrequency excitation pulse and readout of three non‐phase‐encoded k‐space lines. Experiments were performed on an egg white phantom and 26 human subjects on a heavy‐duty clinical scanner, in order to compare the difference of FS‐CEST and NFS‐CEST sequences for generating the z‐spectrum, magnetization transfer ratio asymmetry (MTR_asym) spectrum, and amide proton transfer weighted (APTw) image.

The B₀ drift in CEST imaging, if …