作者
Kyla‐Louise Horne, Michael R MacAskill, Daniel J Myall, Leslie Livingston, Sophie Grenfell, Maddie J Pascoe, Bob Young, Reza Shoorangiz, Tracy R Melzer, Toni L Pitcher, Tim J Anderson, John C Dalrymple‐Alford
发表日期
2021/4
期刊
Movement Disorders Clinical Practice
卷号
8
期号
3
页码范围
390-399
出版商
John Wiley & Sons, Inc.
简介
Background
Neuropsychiatric symptoms in Parkinson's disease (PD) may increase dementia (PDD) risk. The predictive value of these symptoms, however, has not been compared to clinical and demographic predictors of future PDD.
Objectives
Determine if neuropsychiatric symptoms are useful markers of PDD risk.
Methods
328 PD participants completed baseline neuropsychiatric and MDS‐Task Force‐Level II assessments. Of these, 202 non‐demented individuals were followed‐up over a four‐years period to detect conversion to PDD; 51 developed PDD. ROC analysis tested associations between baseline neuropsychiatric symptoms and future PDD. The probability of developing PDD was also modeled as a function of neuropsychiatric inventory (NPI)‐total score, PD Questionnaire (PDQ)‐hallucinations, PDQ‐anxiety, and contrasted to cognitive ability, age, and motor function. Leave‐one‐out information …
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KL Horne, MR MacAskill, DJ Myall, L Livingston… - Movement Disorders Clinical Practice, 2021