作者
Alok Ranjan, Ragini Yerande, Prasad B Wakchaure, Swapnil G Yerande, Dattatraya H Dethe
发表日期
2014/11/7
期刊
Organic letters
卷号
16
期号
21
页码范围
5788-5791
出版商
American Chemical Society
简介
An intramolecular transition-metal-free base-mediated hydroamination of propargylamine with isothiocyanates has been achieved. This atom-economical, regioselective intramolecular 5-exo-dig cycloisomerization was utilized for the one-pot synthesis of diversely substituted imidazole-2-thione and spiro-cyclic imidazolidine-2-thione. The reaction goes to completion at room temperature via propargylthiourea and 65–97% isolated yields were obtained.
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A Ranjan, R Yerande, PB Wakchaure, SG Yerande… - Organic letters, 2014