作者
Robert M Grant, Peter L Anderson, Vanessa McMahan, Albert Liu, K Rivet Amico, Megha Mehrotra, Sybil Hosek, Carlos Mosquera, Martin Casapia, Orlando Montoya, Susan Buchbinder, Valdilea G Veloso, Kenneth Mayer, Suwat Chariyalertsak, Linda-Gail Bekker, Esper G Kallas, Mauro Schechter, Juan Guanira, Lane Bushman, David N Burns, James F Rooney, David V Glidden
发表日期
2014/9/1
期刊
The Lancet infectious diseases
卷号
14
期号
9
页码范围
820-829
出版商
Elsevier
简介
Background
The effect of HIV pre-exposure prophylaxis (PrEP) depends on uptake, adherence, and sexual practices. We aimed to assess these factors in a cohort of HIV-negative people at risk of infection.
Methods
In our cohort study, men and transgender women who have sex with men previously enrolled in PrEP trials (ATN 082, iPrEx, and US Safety Study) were enrolled in a 72 week open-label extension. We measured drug concentrations in plasma and dried blood spots in seroconverters and a random sample of seronegative participants. We assessed PrEP uptake, adherence, sexual practices, and HIV incidence. Statistical methods included Poisson models, comparison of proportions, and generalised estimating equations.
Findings
We enrolled 1603 HIV-negative people, of whom 1225 (76%) received PrEP. Uptake was higher among those reporting condomless receptive anal intercourse (416/519 [81%] vs …
学术搜索中的文章
RM Grant, PL Anderson, V McMahan, A Liu, KR Amico… - The Lancet infectious diseases, 2014