作者
Martin P Grobusch, Bertrand Lell, Norbert G Schwarz, Julian Gabor, Jenny Dörnemann, Marc Pötschke, Sunny Oyakhirome, Georg C Kiessling, Magdalena Necek, Matthias U Längin, Peter Klein Klouwenberg, Anna Klöpfer, Benjamin Naumann, Handan Altun, Selidji T Agnandji, Julia Goesch, Marieluise Decker, Carmen L Ospina Salazar, Christian Supan, Davy U Kombila, Lea Borchert, Kai B Koöter, Peter Pongratz, Akim A Adegnika, Isabelle von Glasenapp, Saadou Issifou, Peter G Kremsner
发表日期
2007/12/1
期刊
The Journal of infectious diseases
卷号
196
期号
11
页码范围
1595-1602
出版商
The University of Chicago Press
简介
Background. Intermittent preventive treatment aims to maximize the protective effects of malaria chemoprophylaxis while minimizing the deleterious effects.
Methods. In Gabon, 1189 infants received either sulfadoxine-pyrimethamine (SP; 250 and 12.5 mg, respectively) or placebo at 3, 9, and 15 months of age. Children were actively followed-up until 18 months of age.
Results. In the intention-to-treat population at 18 months of follow-up, 84 children (17%) in the SP group had ⩾1 episode of anemia, versus 108 (21%) in the placebo group (protective efficacy, 22% [95% confidence interval {CI}, -1% to 40%]; P= .06). In the intervention group, there were 66 episodes during 485 person-years at risk, compared with 79 episodes during 497 years in the placebo group (protective efficacy, 17% [95% CI, -24% to 45%; P = .36). The effects were similar at …
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MP Grobusch, B Lell, NG Schwarz, J Gabor… - The Journal of infectious diseases, 2007