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Osteosarcoma (OS) is a rare disease that accounts for less than 1% of cancers diagnosed in worldwide. Especially, it is a primary malignant bone tumor that is more common in childhood and adolescence (Sampson et. al., 2015). It is known that this disease constitutes approximately 8.9% of the mortalities seen in the pediatric period. Osteosarcoma originates from primary mesenchymal bone stem cells and can develop on any bone in the body especially the tibia, femur, humerus, which have a rich vessel network (Jones, 2011; Li et al., 2016a; Shaikh et al., 2016).

In the pathogenesis of the disease, immature bone cells or osteoid structure formation increase and accumulate on the bone tissue and as a result, swelling, pathological fracture and pain may occur. Because the symptoms are usually severe and painful, the disease is diagnosed within a few months. The disease is diagnosed with X-ray radiography and biopsy. In case of delay in diagnosis, pathological fractures occur as a result of open surgical biopsy (Friebele et al., 2015).