作者
Michelle G Roy, Alessandra Livraghi-Butrico, Ashley A Fletcher, Melissa M McElwee, Scott E Evans, Ryan M Boerner, Samantha N Alexander, Lindsey K Bellinghausen, Alfred S Song, Youlia M Petrova, Michael J Tuvim, Roberto Adachi, Irlanda Romo, Andrea S Bordt, M Gabriela Bowden, Joseph H Sisson, Prescott G Woodruff, David J Thornton, Karine Rousseau, Maria M De la Garza, Seyed J Moghaddam, Harry Karmouty-Quintana, Michael R Blackburn, Scott M Drouin, C William Davis, Kristy A Terrell, Barbara R Grubb, Wanda K O’Neal, Sonia C Flores, Adela Cota-Gomez, Catherine A Lozupone, Jody M Donnelly, Alan M Watson, Corinne E Hennessy, Rebecca C Keith, Ivana V Yang, Lea Barthel, Peter M Henson, William J Janssen, David A Schwartz, Richard C Boucher, Burton F Dickey, Christopher M Evans
发表日期
2014/1/16
期刊
Nature
卷号
505
期号
7483
页码范围
412-416
出版商
Nature Publishing Group UK
简介
Respiratory surfaces are exposed to billions of particulates and pathogens daily. A protective mucus barrier traps and eliminates them through mucociliary clearance (MCC),. However, excessive mucus contributes to transient respiratory infections and to the pathogenesis of numerous respiratory diseases. MUC5AC and MUC5B are evolutionarily conserved genes that encode structurally related mucin glycoproteins, the principal macromolecules in airway mucus,. Genetic variants are linked to diverse lung diseases,,, but specific roles for MUC5AC and MUC5B in MCC, and the lasting effects of their inhibition, are unknown. Here we show that mouse Muc5b (but not Muc5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac is dispensable. Muc5b deficiency caused materials to accumulate in upper and lower …
学术搜索中的文章
MG Roy, A Livraghi-Butrico, AA Fletcher, MM McElwee… - Nature, 2014