作者
Meghan B Azad, Theodore Konya, David S Guttman, CJ Field, MR Sears, KT HayGlass, PJ Mandhane, SE Turvey, P Subbarao, AB Becker, JA Scott, AL Kozyrskyj
发表日期
2015/3/1
期刊
Clinical & Experimental Allergy
卷号
45
期号
3
页码范围
632-643
简介
Background
The gut microbiota is established during infancy and plays a fundamental role in shaping host immunity. Colonization patterns may influence the development of atopic disease, but existing evidence is limited and conflicting.
Objective
To explore associations of infant gut microbiota and food sensitization.
Methods
Food sensitization at 1 year was determined by skin prick testing in 166 infants from the population‐based Canadian Healthy Infant Longitudinal Development (CHILD) study. Faecal samples were collected at 3 and 12 months, and microbiota was characterized by Illumina 16S rRNA sequencing.
Results
Twelve infants (7.2%) were sensitized to ≥ 1 common food allergen at 1 year. Enterobacteriaceae were overrepresented and Bacteroidaceae were underrepresented in the gut microbiota of food‐sensitized infants at 3 months and 1 year, whereas lower microbiota richness was evident …
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MB Azad, T Konya, DS Guttman, CJ Field, MR Sears… - Clinical & Experimental Allergy, 2015