作者
Raj Shree, Whitney E Harrington, Sami B Kanaan, Alexandra Forsyth, Emma Cousin, Anthony Lopez, J Lee Nelson, Hilary S Gammill
发表日期
2019/1
期刊
BJOG: An International Journal of Obstetrics & Gynaecology
卷号
126
期号
1
页码范围
24-31
简介
Objective
To compare fetal microchimerism (FMc) in pregnancies with uncomplicated vaginal delivery (VD) versus caesarean delivery (CD).
Design
Prospective cohort study.
Setting
University of Washington and Fred Hutchinson Cancer Research Center, USA.
Population
Women delivering singleton pregnancies without pertinent antenatal complications with uncomplicated deliveries (n = 36).
Methods
We collected maternal predelivery, postdelivery and umbilical cord blood for each mother–baby pair. Following maternal and fetal genotyping, FMc was measured with quantitative polymerase chain reaction assays targeting fetus‐specific polymorphisms. Quantification of FMc is expressed as genome equivalents (gEq) of fetal DNA/100 000 total gEq tested. FMc detection was evaluated by logistic regression while controlling for total number of cell equivalents tested and clinically relevant covariates. FMc …
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R Shree, WE Harrington, SB Kanaan, A Forsyth… - BJOG: An International Journal of Obstetrics & …, 2019