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Clinical pathology has a major influence on clinical decisions and the past 60 years have seen an evolution brought about by advances in information technology and automation. The impact of the ever-changing technology in regard to responsibilities and training therefore needs continual appraisal. In this article, the authors have drawn on their experience on automation in clinical chemistry and the experience at Monash Medical Centre in Melbourne, Australia where one of the authors is based. Automation in other industries has also been reviewed, since the reasons to automate and the impact of automation have similarities and these include reduction in errors, increase in productivity, and improvement in safety. Advances in technology in clinical chemistry that have included total laboratory automation call for changes in job …