作者
C Bosetti, Ersilia Lucenteforte, DT Silverman, G Petersen, PM Bracci, BT Ji, E Negri, D Li, HA Risch, SH Olson, S Gallinger, AB Miller, H Bas Bueno-de-Mesquita, R Talamini, J Polesel, P Ghadirian, PA Baghurst, W Zatonski, E Fontham, WR Bamlet, EA Holly, P Bertuccio, YT Gao, M Hassan, H Yu, RC Kurtz, M Cotterchio, J Su, P Maisonneuve, EJ Duell, P Boffetta, C La Vecchia
发表日期
2012/7/1
期刊
Annals of oncology
卷号
23
期号
7
页码范围
1880-1888
出版商
Elsevier
简介
Background
To evaluate the dose–response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables.
Methods
We analyzed data from 12 case–control studies within the International Pancreatic Cancer Case–Control Consortium (PanC4), including 6507 pancreatic cases and 12 890 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models.
Results
Compared with never smokers, the OR was 1.2 (95% confidence interval [CI] 1.0–1.3) for former smokers and 2.2 (95% CI 1.7–2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR = 3.4 for ≥35 cigarettes per day, P for trend <0.0001). Risk increased in relation to duration of cigarette smoking up to 40 years of smoking (OR = 2.4). No trend in risk was observed for age at starting …
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C Bosetti, E Lucenteforte, DT Silverman, G Petersen… - Annals of oncology, 2012