作者
Rita Borzsei, Laszlo Mark, Andrea Tamas, Terez Bagoly, Csaba Bay, Katalin Csanaky, Eszter Banki, Peter Kiss, Alexandra Vaczy, Gabriella Horvath, Jozsef Nemeth, Edit Szauer, Zsuzsanna Helyes, Dora Reglodi
发表日期
2009/4
期刊
European journal of endocrinology
卷号
160
期号
4
页码范围
561-565
出版商
Oxford University Press
简介
Objective
Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide widely distributed throughout the body. It is involved in the regulation of various physiological and pathophysiological processes, such as reproduction, thermoregulation, motor activity, brain development, neuronal survival, inflammation and pain. Since little is known about its distribution in humans, our aim was to examine PACAP-38 in human plasma. Furthermore, based on the presence of vasoactive intestinal peptide, structurally the closest to PACAP, in milk and PACAP and its receptors in the mammary gland, our aim was to study PACAP-38 in human milk.
Design and methods
The presence of PACAP-38 was determined by mass spectrometry in plasma samples from healthy male and female volunteers (age: 20–40), as well as in plasma and milk samples …
学术搜索中的文章
R Borzsei, L Mark, A Tamas, T Bagoly, C Bay… - European journal of endocrinology, 2009