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Prenatal cannabis use has been the topic of much clinical, public health, and societal debate in recent years. Growing evidence supports the notion that in utero cannabis exposure is associated with adverse neonatal health outcomes. 1, 2 The study by Marchand et al3 is the latest to contribute to this growing body of evidence. In their systematic review and meta-analysis, Marchand et al3 examined neonatal outcomes of infants with in utero cannabis exposure compared with infants who were not exposed. Importantly, this is among the largest meta-analyses on this topic to date. Findings demonstrated a significant difference in several adverse neonatal outcomes among infants with in utero cannabis exposure, including higher rates of low birth weight (ie,< 2500 g) and small for gestational age (ie,< fifth percentile), lower mean birth weight, preterm delivery (ie,< 37 weeks’ gestation), higher rate of admission to the …