作者
Maie AR St John, Yang Li, Xiaofeng Zhou, Paul Denny, Chih-Ming Ho, Carlo Montemagno, Wenyuan Shi, Fengxia Qi, Benjamin Wu, Uttam Sinha, Richard Jordan, Lawrence Wolinsky, No-Hee Park, Honghu Liu, Elliot Abemayor, David TW Wong
发表日期
2004/8/1
期刊
Archives of Otolaryngology–Head & Neck Surgery
卷号
130
期号
8
页码范围
929-935
出版商
American Medical Association
简介
Background
Since morbidity and mortality rates due to oral cavity and oropharyngeal squamous cell carcinoma (OSCC) have improved little in the past 30 years, early detection or prevention of this disease is likely to be most effective. Using laser-capture microdissection, we have identified the expression of 2 cellular genes that are uniquely associated with OSCC: interleukin (IL) 6 and IL-8. These cytokines may contribute to the pathogenesis of this disease, and have been linked with increased tumor growth and metastasis.
Objectives
To investigate whether IL-6 and/or IL-8 could serve as informative biomarkers for OSCC in saliva and/or serum and to determine if there is a role for saliva as a diagnostic medium for OSCC.
Patients and Methods
Patients with newly diagnosed T1 or T2 oral cavity or oropharyngeal histologically confirmed squamous cell carcinoma were recruited for the study. Age and sex-matched …
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MARS John, Y Li, X Zhou, P Denny, CM Ho… - Archives of Otolaryngology–Head & Neck Surgery, 2004
